To the Editor In the Fluid Loading in Abdominal Surgery: Saline vs Hydroxyethyl Starch (FLASH) trial,1 the sex ratio in both groups was very unbalanced, with 88% of participants being male and 12% female, for a ratio of 7.5 to 1. Other investigations2-4 did not have comparable sex distributions, with ratios being more or less equal.
Markow G. Hydroxyethyl Starch vs Saline for Volume Expansion After Abdominal Surgery. JAMA. 2020;324(2):199. doi:10.1001/jama.2020.6971
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