To the Editor Dr Futier and colleagues reported the effects of HES vs saline in high-risk surgical patients.1 This placebo-controlled trial found no significant difference in the primary end point, a composite of death and preselected major postoperative complications.
Although the patients received significant amounts of fluids, both during the day of surgery and the next day, the study fluids accounted for only a third of the administered fluids on both days (2000 mL in the starch group vs 5500 mL in total intravenous fluids).
De Backer D, Michiels G. Hydroxyethyl Starch vs Saline for Volume Expansion After Abdominal Surgery. JAMA. 2020;324(2):200. doi:10.1001/jama.2020.6974
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