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December 8, 1945


JAMA. 1945;129(15):1014-1016. doi:10.1001/jama.1945.92860490001007

Although the ideal medium for x-ray visualization of the spinal subarachnoid space has not yet been found, pantopaque appears to be the most satisfactory agent thus far introduced for this purpose. It is more irritating than air or other gases used for myelography, but its use results in much better visualization of the subarachnoid space. It is free from the danger of a radioactive substance such as thorotrast, and it causes less severe reactions than tyrogel.1 Its advantages over lipiodol are that it flows more freely within the subarachnoid space, fills the arachnoidal prolongations along the nerve roots better, thus being more suitable for the disclosure of herniated intervertebral disks, it is less apt to show false filling defects and it may be more readily removed from the thecal sac. The meningeal responce to the injection of pantopaque has been described as "minimal and