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December 8, 1945

ACUTE NONSPECIFIC MYOCARDITIS

JAMA. 1945;129(15):1018-1019. doi:10.1001/jama.1945.02860490030009
Abstract

Physicians continue to diagnose myocarditis in the absence of inflammatory disease of the myocardium. The clinical syndrome of cardiac insufficiency is often incorrectly labeled myocarditis.

Acute nonspecific myocarditis is an entity characterized by an acute inflammatory process in the myocardium most often secondary to some acute infectious disease. Saphir,1 who found myocarditis in 240 of 5,626 necropsies, recommends that many sections be taken from the myocardium, since acute myocarditis may involve only small foci as well as extensive areas of the heart muscle. In those who die of an acute infectious disease the primary process frequently so dominates the pathologic picture that the discovery of myocarditis is only secondary. Cases of sudden death from acute infectious disease have incited both the clinician and the pathologist to a careful examination of the myocardium. Jaffe,2 from a careful investigation of 165 cases, concluded that there is a causal relationship between

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