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December 8, 1945

CLAVACIN

JAMA. 1945;129(15):1045. doi:10.1001/jama.1945.02860490057020

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Abstract

To the Editor:—  The editorial on clavacin in The Journal, September 22, in which it is suggested that this antibiotic be used in local ringworm infections, is of great interest. I have for some time been using streptothricin (antibiotic from Actinomyces lavendulae-Waksman 1942) for mild interdigital epidermophytosis in which the objective symptoms consist only of scaling with or without fissuring, in the following formula:If the streptothricin ointment is used in the condition indicated, the scaling and fissuring disappears in four or five days and the skin will continue to remain smooth as long as the streptothricin ointment is used. Lapse in the use of the ointment is followed by gradual return of the scaling, thus indicating fungistatic but partial or no fungicidal activity. The nature of this application indicates probable lack of local sensitizing and certainly nonirritating properties and for this reason should be the preferable one for the

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