Soon after the discovery of insulin in 1923, Banting and his associates 1 noted the manifestations of hypoglycemia when the blood sugar fell below 0.07 per cent under the influence of insulin. They described the typical symptoms, which are familiar today to all who have used insulin, and observed that the condition was relieved by administration of carbohydrate and avoidance of excessive doses of insulin. The condition termed "spontaneous hyperinsulinism" was first suggested by Seale Harris 2 in 1923, and he reported five cases in 1924. In 1926 Warren 3 reported fifteen cases of islet cell tumors from the literature and added four more. The significance of these tumors was not proved until 1927, when Wilder and his associates 4 demonstrated a definite pathologic basis for hypoglycemia due to hyperinsulinism. At operation a pancreatic carcinoma with metastases to the liver, regional nodes and mesentery was found. Autopsy showed that these
HERRMANN SF, GIUS JA. HYPERINSULINISM ASSOCIATED WITH CALCIFIED TUMOR OF THE PANCREASWITH SURGICAL CURE. JAMA. 1937;108(17):1402–1405. doi:10.1001/jama.1937.02780170020007
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