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August 4, 2020

Virus Surveillance and Diagnosis With a CRISPR-Based Platform

JAMA. 2020;324(5):430. doi:10.1001/jama.2020.12669

A newly developed technology draws on the latest genome editing advances to detect viruses at scale—including the one that causes coronavirus disease 2019 (COVID-19)—for surveillance and diagnostic purposes. The innovation, recently described in Nature, uses clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR–associated protein 13 (Cas13), gene editing tools based on a bacterial defense system against invading viruses.