To the Editor My coauthors and I recently undertook a review of the Original Investigation “Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19: A Randomized Clinical Trial,” published online in JAMA on June 3, 2020.1 In this trial, we assessed the effect of convalescent plasma therapy in addition to standard treatment vs standard treatment alone among 103 patients with coronavirus disease 2019 (COVID-19), stratified by disease severity. The primary outcome was time to clinical improvement within 28 days. We found that among patients with severe or life-threatening COVID-19, convalescent plasma therapy added to standard treatment, compared with standard treatment alone, did not result in a statistically significant improvement in time to clinical improvement within 28 days.
Liu Z. Errors in Trial of Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19. JAMA. 2020;324(5):518–519. doi:10.1001/jama.2020.12607
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