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Comment & Response
August 4, 2020

Intravenous Interferon β-1a for Severe ARDS—Reply

Author Affiliations
  • 1Critical Care, University College London Hospitals, London, United Kingdom
  • 2Alma Mater Studiorum–Universitá di Bologna, Bologna, Italy
  • 3Faron Pharmaceuticals Ltd, Turku, Finland
JAMA. 2020;324(5):515-516. doi:10.1001/jama.2020.7992

In Reply Drs Zhou and Tang comment that the survival curves crossed each other in our study,1 and thus they questioned whether the proportionality assumption was met. Although the 1-year survival curves in the Kaplan-Meier plot overlapped at some points, the lines were generally distinct and there was no actual line crossing except at the very end, when there were few patients left in follow-up. In a diagnostic graph of log(−log[survival]) vs log of survival time, there was visible crossing of lines only in the very beginning of the log-time axis. Thus, overall, the time proportionality assumption seemed to hold well. In addition, in a Cox regression model including the evaluation of proportional hazards using the ASSESS statement (SAS proc phreg), no evidence of proportional hazards assumption violation was observed (P > .05). Further testing applying a Cox regression model including evaluation of proportional hazards using an interaction test with log(time) did not reveal a significant interaction (P > .05). In all, no significant deviation from the proportional hazards assumption was noted in visual or statistical evaluation of survival curves or resulting hazards.

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