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April 24, 1937

Current Comment

JAMA. 1937;108(17):1437. doi:10.1001/jama.1937.02780170055019

SUBACUTE COMBINED DEGENERATION IN PERNICIOUS ANEMIA  Great differences of opinion still exist concerning the reaction of the neurologic manifestations of pernicious anemia to specific therapy. A most thorough study of this problem is the report by Hyland and Farquharson1 in the December issue of the Archives of Neurology and Psychiatry. The wide variation of opinion manifest in previous studies indicates, they believe, that there must be differences either in the treatment administered or in the interpretation of the clinical results. In addition to variation in the mode and quantity of antianemic substances prescribed, there are wide fluctuations in the duration and in the amount of rest, both of which are factors of great importance. The patients studied by these investigators included seventy-four persons with pernicious anemia associated with definite subacute combined degeneration of the spinal cord. On admission to the hospital the patients were kept at complete rest in