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December 15, 1945

PHTHALYLSULFATHIAZOLE ("SULFATHALIDINE"): CLINICAL, CHEMICAL AND BACTERIOLOGIC EVALUATIONS IN INFECTIOUS DISEASES OF THE COLON

JAMA. 1945;129(16):1080-1083. doi:10.1001/jama.1945.02860500012004
Abstract

While good results have been obtained with sulfonamides previously utilized in the intestinal canal, one is constantly on the alert for an agent that may approximate perfection. In recent years sulfaguanidine and succinylsulfathiazole (sulfasuxidine)1 have been the two agents most widely used in the management of infectious diseases of the colon. Favorable results were obtained in a large percentage of patients treated with the two sulfonamides just mentioned.

In the evaluation of sulfaguanidine it is my experience that this agent is more toxic than succinylsulfathiazole, that larger dosages are required for optimum results and that the blood concentration determinations reach a higher level. Succinylsulfathiazole, on the other hand, is apparently less toxic and, while large doses have been prescribed orally, the blood levels range between 1 and 1.5 mg. per hundred cubic centimeters of blood irrespective of the duration of administration of the drug, thus indicating that the absorption

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