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December 15, 1945


JAMA. 1945;129(16):1094. doi:10.1001/jama.1945.92860500004007

Wartime conditions, with overcrowding of nurseries and inadequate personnel, have caused impetigo neonatorum to assume new importance. This infection is always troublesome and may be followed by furunculosis, erysipelas, cellulitis or general sepsis.

In this study 14 cases were treated with penicillin ointment, with satisfactory results (tables 1 and 2).

METHOD OF TREATMENT  The penicillin ointment used in this study was always freshly made. It was prepared by taking up a stock solution of penicillin in a eucerite type base (5 per cent by weight) and dispersing in White Ointment U. S. P. XII. For the first part of the study the ointment was made with 250 units of penicillin to each gram, but this was later increased to 333 units to each gram.Each new case of impetigo neonatorum was strictly isolated. The exfoliated membrane of epidermis, which constitutes the bleb, was