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December 15, 1945


JAMA. 1945;129(16):1098. doi:10.1001/jama.1945.02860500030012

Intravenous injection of a single dose of 600,000 units of streptomycin in man, according to Zintel and his co-workers,1 was followed by a concentration of the drug in the blood which decreased at a more or less uniform rate for six hours. Fifteen minutes after administration the average blood streptomycin level was 32.8 units. At the end of six hours a small amount of streptomycin, 4.9 units per cubic centimeter, was still detectable in the blood in the majority of instances. When the same amount of streptomycin was administered as a single dose subcutaneously, the maximum blood level was not attained until two or three hours later. An additive effect was obtained when the drug was administered every three hours. When 3,000,000 units of streptomycin in 3,000 cc. of a 5 per cent glucose solution was administered daily by continuous intravenous infusion, the blood streptomycin levels usually varied between