Over-the-counter biotin supplements, especially in high dosages (≥5 mg/d, or 166-fold greater than the dietary recommendation of 30 μg/d), are widely available and marketed as having health benefits such as stimulating growth of hair and nails. The US Food and Drug Administration (FDA) issued a safety communication in 2017 warning that high-dosage biotin supplement use may interfere with laboratory test accuracy.1 To understand the potential clinical implications of high-dosage biotin supplement use, we characterized the prevalence and trends in use of 1 mg/d or greater and 5 mg/d or greater of biotin among US adults from 1999 to 2016. A biotin dosage of 1 mg/d or greater was chosen because lower dosages (<1 mg/d) are unlikely to interfere with laboratory tests; a dosage of 5 mg/d or greater was studied because biotin supplements for hair and nail growth often contain 5 mg/d or more.
Li D, Rooney MR, Burmeister LA, Basta NE, Lutsey PL. Trends in Daily Use of Biotin Supplements Among US Adults, 1999-2016. JAMA. 2020;324(6):605–607. doi:10.1001/jama.2020.8144
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