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To the Editor:—
Since Link and his associates demonstrated a hypoprothrombinemic effect of salicylates in rats using 12.5 per cent plasma, the clinical significance in man of this finding has been in question. Despite the fact that unequivocal reports of actual hemorrhagic complications developing during salicylate therapy are rare, The Journal saw fit to call attention to the potential dangers in an editorial (Hazards in the Salicylate Treatment of Rheumatic Fever, Feb. 24, 1945, p. 460).A great opportunity to throw light on this question has arisen with the large number of rheumatic fever cases seen in the armed forces which have been treated with large doses of salicylates, reports of which are now appearing. With doses as large as 10 to 15 Gm. daily continued over long periods, salicylate levels as high as 30 to 60 mg. per hundred cubic centimeters have commonly been attained with some increase in
Higley CS. USE OF SALICYLATES IN RHEUMATIC FEVER—MIXTURE OF ASPIRIN AND VITAMIN K UNWARRANTED. JAMA. 1945;129(16):1123–1124. doi:10.1001/jama.1945.02860500055027
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