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December 22, 1945

TREATMENT OF PREPARALYTIC POLIOMYELITIS WITH GAMMA GLOBULIN

JAMA. 1945;129(17):1146-1150. doi:10.1001/jama.1945.02860510012003
Abstract

By July of 1944 it was obvious that New York State was about to experience a major epidemic of poliomyelitis. Dr. John B. Alsever of the U. S. Public Health Service, temporarily assigned to the New York State Health Department in connection with the development of its plasma program, saw in the situation an excellent opportunity to study the possible therapeutic effect of the gamma globulin fraction of pooled plasma1 in poliomyelitis. At that time collaborators of Enders2 had already reported finding poliomyelitis antibodies in fraction II + III of human plasma in concentrations ten times as great as in whole plasma. Moreover, it was found that a number of other antibodies, similarly concentrated four to ten fold in fraction II + III, were associated with the gamma globulins, since they were further concentrated2 fifteen to thirty fold over plasma in fraction II,1 which contains 80 to 95

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