The global burden of hypertension and diseases causally linked to it is substantial. In 2015, among 30 environmental, behavioral, and metabolic risk factors for diseases resulting in the highest levels of disability-adjusted life-years, high blood pressure ranked No. 1.1 Further analyses revealed that from 1990 to 2015, the worldwide rate of elevated systolic blood pressure levels increased substantially, as did deaths and disability-adjusted life-years related to high systolic blood pressure.2 Increasing risks of death and disability were observed even at systolic blood pressure levels of 110 mm Hg to 115 mm Hg.