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December 22, 1945

Foreign Letters

JAMA. 1945;129(17):1219-1221. doi:10.1001/jama.1945.02860510085020

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Abstract

LONDON  (From Our Regular Correspondent)Nov. 17, 1945.

A New British Antimalarial Drug  The loss of Java early in the war resulted in a worldwide shortage of quinine. Much was done in this country and the United States to find new drugs for the treatment of malaria. A new drug has been discovered in the laboratories of the Imperial Chemical Industries, a British firm, which is to be distributed under the name of paludrine. Its composition is not disclosed but the following information was reported to the Medical Research Council during the development of the substance. Early in 1942 a group of chemists and biologists began the search for a new synthetic antimalarial drug which could not only replace quinine but be more effective in preventing and treating malaria. Antimalarial activity was found in several compounds, but not until 1944 was a satisfactory compound synthesized. It was remarkably active against

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