In Reply Dr Asnis emphasizes the importance of pharmacological treatments for tinnitus, which were not addressed in our Clinical Update.1 Although we disagree with his assertion that nonpharmacological treatments are ineffective in many, his letter does raise several good points about the comorbid conditions of insomnia and depression and the role that pharmacotherapy, especially hypnotics and antidepressants, may play. Unfortunately, no drug has “demonstrated replicable, long-term reduction of tinnitus impact in excess of placebo effects,”2 and there is no drug approved by the US Food and Drug Administration for tinnitus.
Piccirillo JF, Rodebaugh TL, Lenze EJ. Pharmacological Treatments for Tinnitus—Reply. JAMA. 2020;324(11):1109–1110. doi:10.1001/jama.2020.11868
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: