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Comment & Response
September 15, 2020

Pharmacological Treatments for Tinnitus—Reply

Author Affiliations
  • 1Department of Otolaryngology–Head & Neck Surgery, Washington University School of Medicine, St Louis, Missouri
  • 2Editor, JAMA OtolaryngologyHead & Neck Surgery
  • 3Department of Psychology, Washington University, St Louis, Missouri
  • 4Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri
JAMA. 2020;324(11):1109-1110. doi:10.1001/jama.2020.11868

In Reply Dr Asnis emphasizes the importance of pharmacological treatments for tinnitus, which were not addressed in our Clinical Update.1 Although we disagree with his assertion that nonpharmacological treatments are ineffective in many, his letter does raise several good points about the comorbid conditions of insomnia and depression and the role that pharmacotherapy, especially hypnotics and antidepressants, may play. Unfortunately, no drug has “demonstrated replicable, long-term reduction of tinnitus impact in excess of placebo effects,”2 and there is no drug approved by the US Food and Drug Administration for tinnitus.