The successful current use of quinacrine (atabrine), orally and intramuscularly, in treating malaria has not relegated quinine to the scrap-heap of obsolete medicinals for this infection. Quinine has been widely used intravenously in civilian practice and in the armed services as an emergency measure in, or for initiating treatment of, the embolic or cerebral form of the disease, especially with coma. The effectiveness of the quinine, under these conditions, has not been challenged, but the safeness of the procedure has been considerably debated.
In general, clinical reports1 have been rather opinionated without substantial support of the claims for or against using quinine intravenously. The possible hazard in the circulatory depression from quinine has been consistently recognized, although the intravenous procedures used have not always considered measures for controlling or combating this. The alkaloid has been given empirically with or without an antagonist. Intravenous epinephrine has been condemned by some
HANZLIK PJ, CUTTING CC. CLINICAL TRIALS WITH QUININEEPINEPHRINE INTRAVENOUSLY. JAMA. 1945;129(18):1241–1243. doi:10.1001/jama.1945.02860520009002
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