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December 29, 1945


JAMA. 1945;129(18):1286. doi:10.1001/jama.1945.02860520054020

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To the Editor:—  May I point out that the paper of Dr. Harold R. Griffith "Curare and Anesthesia," which was published in The Journal, March 17, is incomplete in its history of the use of the drug. He states that "clinicians had more than once cast hopeful eyes toward the possible use of curare in the treatment of spastic disease of the muscles but always its poisonous reputation and the presence of cardiac depressants and other adulterants in the available supplies made clinical trial seem too dangerous." This statement may have been true with specimens of curare antedating the use of the curare which was biologically assayed for me by Merck & Co. and used in many cases of spastic paralysis and allied conditions such as dystonia.The first paper, "Curare Therapy for the Release of Muscle Spasm and Rigidity in Spastic Paralysis and Dystonia Musculorum Deformans," was published in

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