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December 29, 1945


JAMA. 1945;129(18):1286. doi:10.1001/jama.1945.02860520054021

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To the Editor:—  In reply to a recent query concerning the use of A and B group substances to render group O blood safe for use for recipients of all blood groups, the statement was made that there is still no direct evidence establishing the efficacy of the group substances in vivo, when used in this way (The Journal, Nov. 17, 1945, p. 840). Our purpose in this communication is to describe briefly some recent experiments which supply this direct evidence.Group B plasma having a very high titer of anti-A agglutinins was obtained from a blood donor who had been immunized by an injection of soluble group substances. The titer of the anti-A agglutinin for A2 cells by the well slide method reached as high as 2,500 units (equivalent to 10,000 units by the tube technic or about two hundred times the average normal titer) but had fallen

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