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May 8, 1937


Author Affiliations

Adjunct Attending Physician, Beth Israel Hospital; Assistant Visiting Physician, Gouverneur Hospital NEW YORK

JAMA. 1937;108(19):1601-1603. doi:10.1001/jama.1937.02780190017007

Advances in biochemistry have shown that the behavior of human beings is in a great degree dependent on the stability of metabolic processes. If the metabolism of an individual is in some manner disturbed, he responds with a reaction entirely abnormal and is said to be suffering from a "disease."

The importance of metabolism is generally known, yet the progress in our knowledge of infectious diseases and bacteria have in some way relegated the metabolic disorders into the background of clinical values. Disorders of metabolism produce symptom complexes as variable as individuals in their constitutional make up. Human beings are particularly sensitive to humoral changes. Such changes as excessive intake or loss of water will produce abnormal reactions. Changes in the mineral or colloidal constituents of the body, such as loss of salts or plasma proteins, will produce varied clinical pictures. An excess of sugar, as well as a lack

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