Stimulated by the publications of Besredka1 on the streptococcus and staphylococcus "antivirus," and realizing the lack of standardization in the treatment of gonorrhea in men, women and children, I made a determined effort in the summer of 1928 to produce a similar product for the treatment of neisserian infections. Up to the present time there have been no published reports in German, English or American literature of any similar product having been produced from the gonococcus.
However, in 1927 Barbilian, Vosebeoinie and Franke2 reported (in France) an experience in the treatment of gonococcal anterior urethritis by means of local injections of so-called antivirus. Sixteen men with acute gonorrhea were treated and fourteen were said to be clinically and bacteriologically cured. The gonococci were cultivated in an ascitic fluid medium. Bertarelli3 (in Italy) made similar clinical experiments but his results were so discouraging that he gave up the
CORBUS BC. INTRADERMAL IMMUNIZATION IN GONORRHEA: AN EXPERIMENTAL AND CLINICAL REPORT. JAMA. 1932;98(7):532–537. doi:10.1001/jama.1932.02730330014004
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