Of the estimated 5 million patients in the US diagnosed with heart failure (HF), approximately 50% have HF with preserved ejection fraction (HFpEF),1,2 and its prevalence is increasing by about 1% annually relative to that of heart failure with reduced ejection fraction (HFrEF).3 The mortality associated with HF is substantial, and HF was estimated to account for more than 80 000 deaths annually in the US as of 2017.4 In addition, because HF is projected to account for an estimated $69.8 billion in annual health care spending by 2030, HFpEF represents an important public health issue that will increase as the population ages, with a concurrent increasing prevalence of associated risk factors, including hypertension, obesity, and diabetes.4
Clark KAA, Velazquez EJ. Heart Failure With Preserved Ejection Fraction: Time for a Reset. JAMA. 2020;324(15):1506–1508. doi:10.1001/jama.2020.15566
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