In his volume on the physiology of muscular exercise, Bainbridge1 remarked more than a decade ago that the real value of exercise probably lies mainly in its effects on the metabolism of the tissues themselves. Some investigators have looked to changes in the heart and in the circulatory and respiratory mechanisms as the foremost factors involved in that adjustment described as physical training. The trained athlete is supposed to work more "efficiently" than his untrained companion; but as efforts to interpret the advantage in terms of increased efficiency of breathing or circulation alone have not been convincing in every instance, one must look elsewhere for a tenable explanation. The muscle cells at once suggest themselves as the center of interest. Is their characteristic exchange of energy altered? If so, this should exhibit itself in an altered basal metabolism. Recognizing that metabolism is a cellular process, that each living cell
PHYSICAL TRAINING AND METABOLISM. JAMA. 1932;98(7):557–558. doi:10.1001/jama.1932.02730330039014
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