To the Editor Dr Young and colleagues1 suggested that there are occasions when clinicians may treat statistically nonsignificant results as clinically meaningful and incorporate them in important clinical decision-making, especially when considering the effect size and associated confidence intervals. This recommendation is problematic because it elevates underpowered studies in clinical decision-making. Even more problematic in this context is the assumption that inferences can be made directly from group-level data to the individual, even if the group-level results are ambiguous or nonsignificant.