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Comment & Response
October 27, 2020

Evaluating Non–Statistically Significant Results From Trials in Practice

Author Affiliations
  • 1Department of Psychological and Brain Sciences, Boston University, Boston, Massachusetts
JAMA. 2020;324(16):1679-1680. doi:10.1001/jama.2020.15648

To the Editor Dr Young and colleagues1 suggested that there are occasions when clinicians may treat statistically nonsignificant results as clinically meaningful and incorporate them in important clinical decision-making, especially when considering the effect size and associated confidence intervals. This recommendation is problematic because it elevates underpowered studies in clinical decision-making. Even more problematic in this context is the assumption that inferences can be made directly from group-level data to the individual, even if the group-level results are ambiguous or nonsignificant.

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