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JAMA Diagnostic Test Interpretation
October 30, 2020

Urinary Magnesium in the Evaluation of Hypomagnesemia

Author Affiliations
  • 1Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas
  • 2Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina
JAMA. 2020;324(22):2320-2321. doi:10.1001/jama.2020.18400

A 63-year-old woman with a medical history of type 2 diabetes, atrial fibrillation, hypothyroidism, and hypertension was referred for refractory hypomagnesemia. Her blood pressure was 148/68 mm Hg, heart rate 96/min, and weight 106.4 kg. Medications included liraglutide, metformin, apixaban, sotalol, metoprolol, levothyroxine, venlafaxine, lisinopril, ranitidine, and magnesium oxide (400 mg, 2 times/d). Her prior serum magnesium levels ranged from 1.4 mg/dL to 1.6 mg/dL and a recent hemoglobin A1c level was 10.8%. Following baseline blood testing (Table), the patient collected a 24-hour urine sample after discontinuing magnesium supplements for 24 hours.

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