The treatment of malignant tumors complicated by pregnancy is always a major therapeutic problem, especially if the patient refuses interruption of the pregnancy. The consensus of medical opinion strongly advocates the early sacrifice of the fetus when radiation therapy to either the pelvis or the abdomen is indicated, for experience has shown that therapeutic irradiation of the abdomen during gestation is extremely prejudicial to the future health of the fetus.
The apparent rarity of hypernephroma in gravid women is not remarkable if one bears in mind that this tumor usually occurs beyond the reproductive age. In our laboratory we do not designate as hypernephroma those tumors showing sex symptoms and invading the kidney from without, though these have frequently in the past been diagnosed both clinically and pathologically as hypernephromas. The new interpretation disagrees with Grawitz's original conception that tumors of the latter growth arise from cortical adrenal rests but
HENRIKSEN E, SPENCE JM. HYPERNEPHROMA ASSOCIATED WITH PREGNANCY: REPORT OF CASE. JAMA. 1937;108(22):1866–1868. doi:10.1001/jama.1937.02780220024006
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