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JAMA Clinical Guidelines Synopsis
January 5, 2021

Management of Patients With a Patent Foramen Ovale With History of Stroke or TIA

Author Affiliations
  • 1University of Chicago, Chicago, Illinois
JAMA. 2021;325(1):81-82. doi:10.1001/jama.2020.22176

The prevalence of PFOs in the general population is approximately 25%. Patent foramen ovales are usually clinically silent, although they are associated with stroke.1,2 Only recently have large-scale data suggested a benefit of PFO closure for secondary stroke prevention. This AAN guideline updates previous guidelines, incorporating recent data on the effect of PFO closure and antithrombotic and antiplatelet therapy on stroke risk.