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Comment & Response
January 5, 2021

Postexercise Ankle-Brachial Index Testing to Diagnose Peripheral Artery Disease—Reply

Author Affiliations
  • 1Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia
JAMA. 2021;325(1):89-90. doi:10.1001/jama.2020.22490

In Reply Dr Mahé and colleagues are concerned about the sensitivity and specificity of the thresholds used for diagnosing PAD in patients with normal (1.00-1.40) or borderline (0.91-0.99) resting ABI and exertional non–joint-related leg pain.1,2 The diagnostic threshold of either a postexercise ABI decrease of more than 20% or a postexercise ankle systolic pressure decrease of more than 30 mm Hg were suggested by Aboyans et al3 as a reasonable diagnostic criterion for PAD (recommendation class IIa; level of evidence A) in the 2012 American Heart Association scientific statement on measurement and interpretation of the ABI.

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