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June 12, 1937

DIABETES MELLITUS: REPORT OF A CASE RESISTANT TO INSULIN BUT RESPONSIVE TO A CHANGE IN THE TYPE OF CARBOHYDRATE FED

Author Affiliations

NEW YORK

From the Babies Hospital and the Department of Diseases of Children of Columbia University College of Physicians and Surgeons.

JAMA. 1937;108(24):2016-2020. doi:10.1001/jama.1937.02780240008004
Abstract

Since the introduction of insulin, cases have appeared from time to time that showed most of the symptoms and signs of diabetes mellitus but did not respond to insulin. The physiologic explanation behind most of these conditions is still obscure. For this reason we are reporting the following case, which was insulin resistant but did respond to a change in the type of monosaccharide derived from the food:

H. W., a white boy, aged 25 months, was admitted to Babies Hospital July 11, 1935, for malnutrition and glycosuria. The family history was irrelevant. The patient had had repeated respiratory infections with otitis media and one attack of bronchopneumonia. He was small at birth and gained very slowly in spite of adequate amounts of food and vitamins. The weights were: at birth 4 pounds 14 ounces (2,213 Gm.); at one year 12 pounds (5,443 Gm.); at eighteen months 13 1/2 pounds

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