Since Zondek1 first reported myxedema heart in 1918 there has been an increasing number of cases recorded. In 1925 Fahr2 could find but eight cases with roentgenologic and electrocardiographic studies. At that time he described three cases that he had seen during the past year, one of which was reported in detail and two in outline. In 1932 he3 described the further progress of one of the preceding cases and reported five additional cases that he had seen in the preceding eight years. Of seventeen cases of severe and moderately severe myxedema, thirteen showed signs and symptoms of heart failure, of which five were severe.
Willius and Haines4 in 1925 referred to Fahr's first paper and reported a study of 162 cases of high grade myxedema without finding a single characteristic case of myxedema heart. One hundred and forty-eight (91 per cent) were free of subjective or objective signs of
Allen WH. THE MYXEDEMA HEART. JAMA. 1937;108(24):2037–2039. doi:10.1001/jama.1937.92780240004008c
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