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February 9, 2021

Searching for the Optimal Exercise Training Regimen in Heart Failure With Preserved Ejection Fraction

Author Affiliations
  • 1Division of Cardiology, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas
  • 2Cardiovascular Medicine and Geriatrics Sections, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina
JAMA. 2021;325(6):537-539. doi:10.1001/jama.2020.26347

Heart failure with preserved ejection fraction (HFpEF) is increasing in prevalence, associated with high morbidity and mortality, and continues to be refractory to available pharmacotherapies.1 HFpEF is a multiorgan disease with complex pathophysiology that culminates in debilitating exercise intolerance as its essential clinical manifestation.2 Exercise intolerance is preceded by an accelerated decline in exercise capacity, measured objectively as peak exercise oxygen consumption (peak V̇o2),3 and manifests clinically as dyspnea, fatigue, and reduced quality of life (QoL). Accordingly, there is an increasing emphasis on developing therapeutic approaches to improve exercise capacity and QoL in patients with HFpEF.