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June 26, 1937


JAMA. 1937;108(26):2182-2184. doi:10.1001/jama.1937.02780260010003

The increasing number of inquiries coming from physicians in various sections of the country makes it desirable to publish at this time a note on the results of recent work on chemoprophylaxis in experimental poliomyelitis and to suggest a procedure which may hold something of practical value in controlling the spread of this disease in man during epidemic periods.

The more fundamental aspects of the disease which initiated these studies have been summarized by one of us in an earlier article in The Journal.1 The chief facts that need to be carried in mind to follow the logic of this new approach are briefly as follows:

  1. The disease is caused by a highly neurotropic virus, which in size is among the smallest of known ultramicroscopic viruses.2

  2. In monkeys, and probably in man also, the virus reaches the central nervous system by way of the olfactory nerve. Complete