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June 26, 1937


JAMA. 1937;108(26):2205. doi:10.1001/jama.1937.02780260033012

Recently evidence was discussed1 in support of the view that ulcers produced in the gastro-intestinal tract of dogs by certain experimental procedures are due chiefly to the corrosive action of excessive amounts of free acid in the chyme. The increase in the free acidity of the gastric contents may result from either an increased secretion of acid, as some believe to be the case frequently in human ulcer, or from a decrease in the amount of available neutralizing alkali, particularly in the duodenum. The latter factor appears to be of primary importance in the production of ulcer in dogs by surgical procedures. It was stated also that within wide limits the concentration of pepsin appears of little importance, granted of course, that some of the enzyme is present.

Recently also further studies on ulcers produced surgically in the dog have been reported.2 This work like-wise serves to emphasize