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July 3, 1937

ARTIFICIAL FEVER THERAPY OF GONORRHEA IN THE MALEA COMPARATIVE STUDY

JAMA. 1937;109(1):18-20. doi:10.1001/jama.1937.02780270020006
Abstract

Our purpose in this report is to present a series of clinical studies of gonorrhea in the male treated with artificial fever therapy compared with a similar series of cases treated by more time-honored methods. If a therapeutic measure is to be properly evaluated, the terms of clinical experimentation should approximate the more exact methods of the laboratory. Fever therapy should be no exception to this generalization. Because of the fundamental work of Warren, Carpenter, Boak and their associates1 together with numerous more purely clinical studies,2 we felt justified in setting up a clinical experiment of this type. Our object was to study one group of young men whom we treated with artificial fever; at the same time and under as nearly identical conditions as possible we studied a second group of young men whom we treated with irrigations, injections and massages.

We determined that, from our point

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