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Research Letter
April 6, 2021

Trends in Age at Natural Menopause and Reproductive Life Span Among US Women, 1959-2018

Author Affiliations
  • 1Department of Public Health, Texas Tech University Health Sciences Center, Lubbock
  • 2Division of Cardiology, Johns Hopkins University, Baltimore, Maryland
  • 3Division of Cardiovascular Sciences, University of California, Davis, Sacramento
  • 4Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee
  • 5Division of Endocrinology, Metabolism, and Diabetes, University of Louisville, Louisville, Kentucky
JAMA. 2021;325(13):1328-1330. doi:10.1001/jama.2021.0278

Menopause, the permanent cessation of menstruation for more than 12 consecutive months resulting from the loss of ovarian function, marks the end of a woman’s reproductive cycle.1 Trends of increasing age at natural menopause have been reported worldwide.2 Understanding changes in the timing of age at natural menopause and length of reproductive life span (age at menopause minus age at menarche) and their associated factors are important because they influence multiple health conditions.1 This study investigated 60-year trends in age at natural menopause and reproductive life span as well as associated factors among US women.