To the Editor In a recent JAMA study,1 administration of sodium nitrite did not significantly improve survival to hospital admission after out-of-hospital cardiac arrest. This result is contrary to animal studies that have shown a protective effect of sodium nitrite in the process of ischemia and reperfusion.2 In the study by Dr Kim and colleagues,1 sodium nitrite was administered in patients over a longer period than in the animal studies, and that may have contributed to the negative outcome.
Sang W, Xu F. Effect of Sodium Nitrite on Survival of Cardiac Arrest to Hospital Admission. JAMA. 2021;325(20):2118. doi:10.1001/jama.2021.4064
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