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Comment & Response
May 25, 2021

Effect of Sodium Nitrite on Survival of Cardiac Arrest to Hospital Admission

Author Affiliations
  • 1Department of Emergency Medicine, Qilu Hospital of Shandong University, Jinan, China
JAMA. 2021;325(20):2118. doi:10.1001/jama.2021.4064

To the Editor In a recent JAMA study,1 administration of sodium nitrite did not significantly improve survival to hospital admission after out-of-hospital cardiac arrest. This result is contrary to animal studies that have shown a protective effect of sodium nitrite in the process of ischemia and reperfusion.2 In the study by Dr Kim and colleagues,1 sodium nitrite was administered in patients over a longer period than in the animal studies, and that may have contributed to the negative outcome.