Notwithstanding the important advances that have been made during the past few years in the treatment of pernicious anemia and in the partial elucidation of the chemical nature of the material effective in the treatment of this disease, the fundamental cause of the anemia remains unsolved. Whipple1 believes that the underlying cause may be a lack of material needed for the formation of the stroma of erythrocytes and therefore that the cells formed are of subnormal structural strength. Some insight into this question may be acquired when the chemical constitution and the mode of action of the antianemic principle are determined. Another approach to the problem, however, is the study of the chemical composition and the physical structure of erythrocytes from patients with typical pernicious anemia. Possibly the disease is associated with changes in the red cell or, indeed, the anemia may be a result of chemical abnormalities of
ERYTHROCYTES IN PERNICIOUS ANEMIA. JAMA. 1937;109(6):434. doi:10.1001/jama.1937.02780320036014
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