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August 7, 1937


JAMA. 1937;109(6):435-436. doi:10.1001/jama.1937.02780320037016

Although there has been much research on the problem of ossification and its characteristic features, some of the most important aspects of this process remain obscure. Chief among these are the mechanism by which calcium is deposited in the bone matrix and the nature of the immediate stimulus that leads to the formation of bone in a given location. The suggestions offered to answer some of these perplexing problems of ossification have in general taken one of two directions. One theory of ossification may be termed humoral or chemical, and Leriche and Policard,1 who have championed this hypothesis, postulate "a local calcific surcharge as the determinant of osteogenesis in a suitable fibrous medium." These authors emphasize the rarefaction of bone at the extremities of the fragments that occurs after a fracture. They believe that this liberates calcium in the region and leads to a local excess of calcium, this

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