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August 14, 1937

STUDIES ON TETANUS TOXOID: II. ACTIVE IMMUNIZATION OF NORMAL PERSONS WITH TETANUS TOXOID, ALUM PRECIPITATED, REFINED

Author Affiliations

CHESTER, PA.

JAMA. 1937;109(7):481-484. doi:10.1001/jama.1937.02780330009003
Abstract

Thirty-four adults were actively immunized against tetanus. Treatment consisted of two injections of tetanus toxoid, alum precipitated, refined, no. 5969-1, given to all but one subject, ninety-two days apart. Patient 34 received the second dose 122 days after the first injection. Sixteen members of the group were given 0.5 cc. of the alum toxoid at each injection, while the rest received a 1 cc. dose.

The alum precipitated toxoid used in this study was prepared at the Mulford Biological Laboratories, from a lot of tetanus toxin that contained over 20,000 minimal lethal doses per cubic centimeter. Antigenic tests performed with this toxoid showed that the injection of 0.5 cc. into standard guinea-pigs produced at the end of six weeks 5 units of tetanus antitoxin per cubic centimeter of blood serum. The injection of 1 cc. of this toxoid also produced 5 units. Similar values were obtained after the injection of

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