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August 14, 1937

CROSS REACTIONS IN AGGLUTINATION TESTS

JAMA. 1937;109(7):522. doi:10.1001/jama.1937.02780330050021

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Abstract

To the Editor:—  The incitants of typhoid fever, undulant fever and tularemia differ from one another in cultural characteristics. So-called cross reactions may occur, however, in agglutination tests with specimens of blood from some of the patients with these infections. Edward Francis (Symptoms, Diagnosis and Pathology of Tularemia, The Journal, Oct. 20, 1928, p. 1155) has called attention to reactions with Brucella abortus in serums from patients with tularemia. According to Gilbert and Coleman (Incidence of Tularemia in New York State, Am. J. Pub. Health22:1249 [Dec.] 1932) the blood from patients with undulant fever rarely has been found to agglutinate Bacterium tularense. Occasionally, however, Bacillus typhosus may be agglutinated. An example of the confusing serologic reactions which sometimes are obtained may be of interest: A young man developed undulant fever, with the date of onset in June 1936. His blood was found to agglutinate Bacillus typhosus definitely and

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