The search continues unabated for the causative agent of eclampsia, which Zweifel has called "the disease of the theories," and of the toxemic states leading to eclampsia, variously known as preeclamptic toxemia, low reserve kidney, eclampsism or eclamptogenic toxemia. Will a single causative agent ever be found? What part do heredity, diet, climate, race, parity and constitution play in the occurrence of these conditions? Why was the incidence of eclampsia and the toxemic states of pregnancy so greatly diminished in central Europe during the World War? Was it due to the restricted ration, particularly poor in proteins and fats, brought about by the enemies' blockade? Why are the more obese plethoric women and primiparas more susceptible? In how many women with toxemia is there a history of some recent acute process that has not been elicited or, if known, has been disregarded as being too remote to have any possible
PREDISPOSING FACTORS IN THE LATE TOXEMIAS OF PREGNANCY. JAMA. 1937;109(8):588–589. doi:10.1001/jama.1937.02780340044014
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