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September 4, 1937

THE DEGREE AND PREVALENCE OF VITAMIN A DEFICIENCY IN ADULTS: WITH A NOTE ON ITS EXPERIMENTAL PRODUCTION IN HUMAN BEINGS

Author Affiliations

From the Fifth (Boston University) Medical Service, Boston City Hospital, and the Department of Medicine, Boston University School of Medicine.

JAMA. 1937;109(10):756-762. doi:10.1001/jama.1937.02780360004002
Abstract

The changing status of the vitamin deficiencies in this country is well shown by recent publications1 emphasizing the rarity of the fully developed, classic diseases and the frequency of the milder deficiencies. This is particularly true with regard to vitamin A deficiency. In a preliminary report, the present knowledge concerning the biochemical and physiologic aspects of vitamin A, the clinical and pathologic aspects of vitamin A deficiency, the mechanism of night blindness and methods of detecting mild degrees of deficiency were reviewed.2 The present study deals chiefly with personal observations, and reference will be made to but a few pertinent papers. Complete bibliographies are available elsewhere.3

PROCEDURE  The material forming the major portion of this paper was obtained from a study of the students of Boston University School of Medicine. Each student received a test on the biophotometer,5 and those with very low readings were rechecked

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