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September 23, 2021

Breakthrough Discovery in Protein Structure Prediction and the Promise of New Treatments

Author Affiliations
  • 1Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts
JAMA. 2021;326(14):1369-1370. doi:10.1001/jama.2021.15728

In July 2021, the use of artificial intelligence (AI) led to a breakthrough in an intense, 60-year-long race to solve the protein folding problem. Experts all agreed it was too soon to assess the implications of the breakthrough, but then divided into 2 camps.

Some experts greeted the news cautiously, emphasizing what the advance had not yet achieved. Other scientists—including some who lost the race—called it “totally transformative,”1,2 “revolutionary,”3 and of equivalent importance to the Human Genome Project.3 Most agreed that the discovery was a landmark in biomedical science, with great potential to advance medical practice.

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1 Comment for this article
AlphaFold from Deepmind
John Summerfield, MD FRCP FAASLD | Imperial College London
Nice piece from Dr Komaroff. He tells us that Deepmind is owned by Alphabet and that similar work was done at University of Washington. But he does not tell us where AlphaFold was developed: good old London, England!
CONFLICT OF INTEREST: None Reported
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