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October 19, 2021

Is There a Role for Combined Use of Varenicline and Nicotine Patch or Extended Treatment Duration to Enhance Smoking Cessation?

Author Affiliations
  • 1Division of Cardiovascular Medicine, Kansas City Veterans Affairs Medical Center, Kansas City, Missouri
  • 2Department of Cardiovascular Medicine, University of Kansas Medical Center, Kansas City
JAMA. 2021;326(15):1481-1482. doi:10.1001/jama.2021.14994

Cigarette smoking is the leading cause of morbidity and mortality worldwide, contributing to an estimated more than 6 million deaths annually.1 Combining pharmacotherapy with behavioral interventions is the most effective way to help smokers sustain abstinence.1-3 Pharmacological therapies help smokers adapt to the absence of nicotine after quitting smoking by reducing nicotine withdrawal symptoms. In the general population of smokers, varenicline or a combination of prolonged- and short-acting nicotine replacement therapy (NRT) are the first-line agents for smoking cessation therapy.1-3

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