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Clinical Trials Update
October 26, 2021

Bacterial Immunotherapy Reduced Kids’ Wheezing

JAMA. 2021;326(16):1572. doi:10.1001/jama.2021.18591

Young children who received daily sublingual bacterial immunotherapy had fewer and shorter wheezing attacks in a phase 3 trial in Spain. Nearly 50% of young children have wheezing attacks, often caused by a rhinovirus or respiratory syncytial virus.

The trial included 120 children younger than 3 years who had 3 or more wheezing attacks during the previous year. The children were randomly assigned to receive a pineapple-flavored investigational immunotherapy called MV130 sprayed under the tongue or placebo daily for 6 months.

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