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Clinical Trials Update
October 26, 2021

Salt Substitute Cut Disease and Death Rates in Large Trial

JAMA. 2021;326(16):1572. doi:10.1001/jama.2021.17441

A randomized trial recently reported in the New England Journal of Medicine focused on an important question for older adults with high blood pressure or a previous stroke: Can switching from regular salt to a 75% sodium chloride and 25% potassium chloride substitute help protect against stroke, major cardiovascular events, or death?

Conducted in 600 rural villages in China, the trial involved 20 995 participants aged 60 years or older with high blood pressure or a history of stroke. The villages were randomly assigned to the intervention group using the salt substitute or to a control group using regular salt.

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