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Article
March 26, 1932

THE PARENTERAL USE OF LIVER EXTRACT IN PERNICIOUS ANEMIA

Author Affiliations

BOSTON

From the Medical Clinic of the Peter Bent Brigham Hospital.

JAMA. 1932;98(13):1051-1060. doi:10.1001/jama.1932.02730390005002
Abstract

This report deals with the effects of a simple liver extract for parenteral use in the treatment of pernicious anemia. Although many patients with this disease have no great difficulty in consuming sufficient liver to maintain an essentially normal state of health, the introduction of an extract of liver and of stomach substance as a substitute for liver has made the task easier for some of them. There are circumstances, however, in which it may be of distinct importance to have available an actively potent substance which may be given parenterally.

A number of papers have appeared recently recording the results of parenteral treatment with various liver extracts in small series of cases. Gänsslen1 in 1930 reported on the successful use of daily intramuscular injections of an extract prepared from 5 Gm. of liver. Similar good results have been reported by Schottmüller,2 van Leeuwen,3 Selander4 and

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